Best The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race By Walter Isaacson
Best The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race By Walter Isaacson
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Ebook About The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.Book The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race Review :
Jennifer Doudna and her French colleague, Emmanuel Carpentier, won the 2020 Nobel Prize for Chemistry. They won for their work in CRISPR technology, Gene Editing, and ultimately for Coronavirus testing & vaccines.Walter Isaacson includes mini bios for many of the scientists included in Doudna’s story and there are quite a few. At first, I was frustrated by all the incremental information - get on with it, already! As his worked progressed, peeling the onion of her life’s story, I see the value of understanding the motivation for these scientists; not all are created equally. Many of the details of Doudna’s life are glossed over so don’t expect a Hollywood style biography. Details are given as they relate to people and events of science, her personal life is not.Doudna is an interesting woman due to the fact that she is really quite “normal” in her brilliance for bio chemistry. I was struck by her genuine affection for her co-workers that’s evidenced in the included photos as well as some of the lengths she went to helping her competition. She states that money is not her motivation but “publish or perish” is ingrained in most academics and even that seems to be under developed in Jennifer. THAT will become an issue...Parts of this formidable volume read like a thriller. There’s intrigue, court battles, and friends with misunderstandings. Part Seven consists of 5 chapters that discuss the issues of ethics as relates to DNA and changing the structure of life, ordering the structure of life. Who has the right? Who controls the rights? Is it right at all? These are supremely serious questions that should be considered be every adult.It would be helpful to have some science background when reading this book, but it’s not impossible without it. There are excellent footnotes to assist and if you get the Kindle version, they are interactive, which makes look ups SO much easier! Otherwise, this is definitely a worthy read. It’s very well written, challenging and up to the minute with information on the science of biochemistry and gene editing. The ethical issues should have people talking for a good, long time. The medical manifestations should have people living a healthy, long time. God Bless Us, Everyoneđź“š This book makes the same mistake as many others by implying that CRISPR-Cas9 is all that is needed for gene-editing. In reality, CRISPR-Cas9 by itself can only accomplish half of the task, which is finding the exact location in the genome very specifically and efficiently. To be clear, this is indeed a huge discovery, and Jennifer and Emmanuel's groudbreaking work is well deserved to win the Noble Prize.However, once finding the correct location for editing, all Cas9 can do by itself is cutting the DNA double helix at this location. Nevertheless, cutting alone usually disrupts the target gene by a mechanism called nonhomologous end joining. Human does possess another DNA repair pathway called HDR, which can fix the gene if a DNA template is nearby. Unfortunately, the latter one only works in the dividing cells and its editing efficiency is often miserably low, especially when editing in vivo.For all the above reasons, CRISPR-Cas9 needs to pair with other editing modules to complete the other half of the job, the actual editing, to fully unlock its potential. This is where the base editor or prime editor comes into the scene. Invented by Harvard Chemist David Liu and his postdocs, both base editor and prime editor can offer much higher "editing" efficiency than HDR. And both editors are widely adopted and hailed by the gene-editing labs across the globe since their debut in 2016 and 2019 respectively.As such, it is a major disappointment for this book that Walter Isaacson failed to dedicate at least one complete chapter to highlight base/prime editor and have an interview with David Liu to discuss his transformational work. 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